Shinoda T, Yoshimura K, Kametani F, Isobe T
Biochem Biophys Res Commun. 1983 Dec 16;117(2):587-92. doi: 10.1016/0006-291x(83)91241-x.
In an examination of 16 human immunoglobulin lambda-light chains, one was found to have amino acid substitutions which have not previously been reported for the constant region of the lambda-chains. It involved in two positions: an arginine instead of lysine at position 130, and a leucine for glutamine at position 195 (Sh numbering (1) ). The structural variation is tentatively designated as "Is" marker.
在对16条人免疫球蛋白λ轻链的检测中，发现有一条链在λ链恒定区存在此前未报道过的氨基酸替换。它涉及两个位置：第130位的赖氨酸被精氨酸取代，第195位的谷氨酰胺被亮氨酸取代（按照Sh编号系统(1)）。这种结构变异暂被命名为“Is”标记。
