Weereratne E A, Gregoriadis G, Crow J
Br J Exp Pathol. 1983 Dec;64(6):670-6.
Chronic treatment (10 i.p. injections over 20 days) of Balb/c mice with SM liposomes led to 50 and 300% enlargement of the liver and spleen respectively. No such effect was observed after similar treatment with PC liposomes. Biochemical analysis of the enlarged tissues showed no significant changes in the concentrations of glycolipid, phospholipid and certain hydrolytic enzymes. However, the increase in tissue size was paralleled by an increase in protein content. Light and electron microscopy studies of the enlarged tissues revealed an increase in the number of Kupffer cells and collections of inflammatory cells in the liver and widespread granulomatous inflammation in the spleen. We conclude that SM liposomes, although probably toxic for use as a drug carrier, may serve as a model agent in the study of tissue granulomatous inflammation.
用SM脂质体对Balb/c小鼠进行慢性治疗（20天内腹腔注射10次），导致肝脏和脾脏分别肿大50%和300%。用PC脂质体进行类似治疗后未观察到这种效果。对肿大组织的生化分析表明，糖脂、磷脂和某些水解酶的浓度没有显著变化。然而，组织大小的增加与蛋白质含量的增加平行。对肿大组织的光镜和电镜研究显示，肝脏中库普弗细胞数量增加，有炎性细胞聚集，脾脏中出现广泛的肉芽肿性炎症。我们得出结论，SM脂质体虽然可能作为药物载体有毒性，但可作为研究组织肉芽肿性炎症的模型剂。
