McKenna R J
CA Cancer J Clin. 1984 Jan-Feb;34(1):24-39. doi: 10.3322/canjclin.34.1.24.
Surgery for salivary gland tumors requires technical skill, competence in head and neck anatomy, and a familiarity with a variety of tumors. Benign salivary tumors at all sites should be 100 percent curable, with a local recurrence rate of less than five percent; these local failures should be curable with further surgery. The majority of parotid tumors are benign. Sixty-two percent of patients with malignant parotid tumors will be alive at five years, 54 percent at 10 years, and 47 percent at 15 years. These survival rates for malignant parotid tumors are better than those for malignant tumors in the submaxillary and minor salivary glands and may be explained in part by the presence of a higher percentage of low-grade malignant tumors in the parotid gland. Since most submaxillary gland tumors are malignant, they are more dangerous than parotid tumors. A total of 80 percent of patients with submaxillary gland tumors die as a result of cancer. Almost all minor salivary gland tumors are malignant; curability relates to size, local extension, histology, and nodal metastases. Forty-five percent are alive at five years, and 21 percent at 15 years. Wide-field radical surgical excision is needed for malignant salivary tumors to minimize local recurrences and treatment failures. Future improvement in treatment results will be made possible by increased awareness of this group of tumors, earlier diagnosis when tumors are still small, more radical extirpation, and greater use of postoperative radiation therapy.
涎腺肿瘤手术需要技术技巧、对头颈部解剖结构的精通以及对多种肿瘤的熟悉程度。所有部位的良性涎腺肿瘤应可100%治愈,局部复发率低于5%;这些局部复发通过进一步手术应可治愈。大多数腮腺肿瘤是良性的。62%的腮腺恶性肿瘤患者5年后存活,10年后为54%,15年后为47%。腮腺恶性肿瘤的这些生存率高于颌下腺和小涎腺的恶性肿瘤,部分原因可能是腮腺中低级别恶性肿瘤的比例较高。由于大多数颌下腺肿瘤是恶性的,它们比腮腺肿瘤更危险。共有80%的颌下腺肿瘤患者死于癌症。几乎所有小涎腺肿瘤都是恶性的;治愈率与肿瘤大小、局部扩展、组织学和淋巴结转移有关。45%的患者5年后存活,15年后为21%。涎腺恶性肿瘤需要进行广泛的根治性手术切除,以尽量减少局部复发和治疗失败。通过提高对这类肿瘤的认识、在肿瘤仍较小时进行早期诊断、更彻底的切除以及更多地使用术后放射治疗,未来治疗效果有望得到改善。