Wenzloff N J, Shimp L
Drug Intell Clin Pharm. 1984 Jan;18(1):22-6. doi: 10.1177/106002808401800102.
Primary dysmenorrhea is a common gynecologic disorder. Dysmenorrheic pain normally has an onset of from 2-12 hours before the start of menses and tapers over the next one to two days. Although the exact etiology is unknown, this condition is associated with an increase in prostaglandin F2 alpha. In the past, nonspecific treatments such as heat and exercise were tried, with poor results. Little relief was offered by antispasmodics or low-dose aspirin. Currently, effective therapy for primary dysmenorrhea includes oral contraceptives and prostaglandin synthetase inhibitors. Oral contraceptives should be prescribed only for women who desire contraception and who are candidates for this type of therapy. Prostaglandin synthetase inhibitors can be given to women who do not desire oral contraceptives or those who do not respond to hormonal therapy. Secondary dysmenorrhea should be suspected in women who do not respond to either treatment modality.
原发性痛经是一种常见的妇科疾病。痛经通常在月经开始前2至12小时发作，并在接下来的一到两天内逐渐减轻。尽管确切病因尚不清楚，但这种情况与前列腺素F2α水平升高有关。过去，曾尝试过热敷和运动等非特异性治疗方法，但效果不佳。解痉药或低剂量阿司匹林的缓解作用也很小。目前，原发性痛经的有效治疗方法包括口服避孕药和前列腺素合成酶抑制剂。口服避孕药仅应开给有避孕需求且适合这种治疗方式的女性。前列腺素合成酶抑制剂可用于那些不希望使用口服避孕药或对激素治疗无反应的女性。对两种治疗方式均无反应的女性应怀疑为继发性痛经。
