化合物48/80和氯丙嗪对蟾蜍（副南美蟾蜍）肥大细胞的脱粒作用：一种非溶细胞过程。
Toad (Bufo paracnemius) mast cell degranulation by compound 48/80 and by chlorpromazine: a non-lytic process.
作者信息
Rossinholi G M, Vugman I
出版信息
Eur J Pharmacol. 1983 Dec 9;96(1-2):133-5. doi: 10.1016/0014-2999(83)90540-x.
Toad mast cells are degranulated by compound 48/80 and by chlorpromazine. The former was effective at rather high (100 micrograms/ml) and the latter at low (0.1 mM) concentrations. Toad mast cell degranulation induced by these drugs was characterized by cytoplasmic granule dissolution without cell lysis. The metabolic inhibitor, dinitrophenol, blocked the degranulation induced by both agents. Glucose reversed the inhibition of compound 48/80-induced degranulation. The results indicate that toad mast cell degranulation by compound 48/80 and by chlorpromazine is a non-lytic process.
蟾蜍肥大细胞可被化合物48/80和氯丙嗪诱导脱颗粒。前者在相当高的浓度（100微克/毫升）下有效，而后者在低浓度（0.1毫摩尔）下有效。这些药物诱导的蟾蜍肥大细胞脱颗粒的特征是细胞质颗粒溶解而无细胞裂解。代谢抑制剂二硝基苯酚可阻断这两种药物诱导的脱颗粒。葡萄糖可逆转化合物48/80诱导的脱颗粒的抑制作用。结果表明，化合物48/80和氯丙嗪诱导的蟾蜍肥大细胞脱颗粒是一个非裂解过程。
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