Bohr V, Rasmussen N, Hansen B, Kjersem H, Jessen O, Johnsen N, Kristensen H S
J Infect. 1983 Nov;7(3):193-202. doi: 10.1016/s0163-4453(83)96980-3.
Data on the bacteriological findings, diagnostic measures and clinical course of 875 patients with bacterial meningitis are presented. Findings from the medical records and from a follow-up questionnaire survey of 667 of these cases revealed no significant difference between patients treated with antibiotics before admission (pretreated) and those who were not treated before admission (non-pretreated) with respect to clinical condition on admission, mortality and late sequelae. Pretreatment was, however, associated with a longer duration of symptoms. Apart from cases due to Neisseria meningitidis, there were no significant differences in diagnostic findings between pretreated and non-pretreated cases. In the group of pretreated meningococcal patients, however, positive blood cultures, pleiocytosis in the cerebrospinal fluid (CSF) and positive cultures from sites other than blood and CSF were less frequent than in the non-pretreated cases.
本文呈现了875例细菌性脑膜炎患者的细菌学检查结果、诊断措施及临床病程。对其中667例病例的病历记录及后续问卷调查结果显示，入院前接受抗生素治疗的患者（预处理组）与未接受治疗的患者（非预处理组）在入院时的临床状况、死亡率及晚期后遗症方面无显著差异。然而，预处理与症状持续时间较长有关。除脑膜炎奈瑟菌所致病例外，预处理组和非预处理组的诊断结果无显著差异。然而，在预处理的脑膜炎球菌患者组中，血培养阳性、脑脊液（CSF）中细胞增多以及血和CSF以外部位的培养阳性情况比非预处理组少见。
