Houlsby R D, Ghajar M, Chavez L
J Pharm Sci. 1983 Dec;72(12):1401-3. doi: 10.1002/jps.2600721208.
The effect of EDTA (ethylenediaminetetraacetate), steroids, and preservatives on the antimicrobial activity of 10% sodium sulfacetamide solutions was evaluated in this study by kill rate and minimum inhibitory concentration (MIC) using five representative microorganisms. The results indicate that thimerosal-preserved sulfacetamide solutions containing EDTA are more effective against Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus epidermidis, and Candida albicans than similar paraben-preserved solutions. Furthermore, the addition of EDTA improves the kill rate, but not the MIC, for the Pseudomonas, Serratia, and Candida species regardless of the preservative. The combination of a steroid with sulfacetamide does not affect its antimicrobial activity.
本研究通过杀灭率和最低抑菌浓度（MIC），使用五种代表性微生物评估了乙二胺四乙酸（EDTA）、类固醇和防腐剂对10%磺胺醋酰钠溶液抗菌活性的影响。结果表明，含EDTA的硫柳汞保存的磺胺醋酰钠溶液比类似的对羟基苯甲酸酯保存的溶液对铜绿假单胞菌、粘质沙雷氏菌、表皮葡萄球菌和白色念珠菌更有效。此外，无论使用何种防腐剂，添加EDTA均可提高假单胞菌、沙雷氏菌和念珠菌属的杀灭率，但不会提高其MIC。类固醇与磺胺醋酰钠的组合不影响其抗菌活性。
