二氧化碳诱导的pH变化对离体豚鼠气管对茶碱反应的影响。
Effect of CO2 induced pH changes on the response of isolated guinea pig tracheas to theophylline.
作者信息
Elguindi A S, Stringfield J T, Bransome E D, Speir W A
出版信息
Res Commun Chem Pathol Pharmacol. 1983 Dec;42(3):493-6.
The effect of CO2 induced pH changes on the response of airway smooth muscle to theophylline was studied. Our data show that simulated respiratory acid-base disturbances (pH range 7.0 to 7.8) have no significant effect on the response of isolated guinea pig tracheal cylinders at basal tone to theophylline. On the other hand, tracheal cylinders precontracted with histamine showed a diminished sensitivity to theophylline at pH values above 7.40, and an enhanced sensitivity at pH values below 7.40.
研究了二氧化碳诱导的pH变化对气道平滑肌对茶碱反应的影响。我们的数据表明，模拟的呼吸酸碱紊乱（pH范围7.0至7.8）对处于基础张力的离体豚鼠气管环对茶碱的反应没有显著影响。另一方面，用组胺预收缩的气管环在pH值高于7.40时对茶碱的敏感性降低，而在pH值低于7.40时敏感性增强。
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