Miyabo S, Kishida S, Sugiyama T, Hashimoto T, Fujii Y, Teranishi M
Acta Endocrinol (Copenh). 1984 Jan;105(1):1-5. doi: 10.1530/acta.0.1050001.
In order to investigate the effects of 2-hydroxyoestradiol (2-OHE2) and 4-hydroxyoestradiol (4-OHE2) on the release of human pituitary hormones, each steroid (500 micrograms single bolus) was injected to young women during the follicular phase. Both steroids resulted in a transient suppression followed by a small rise of LH and FSH. 4-OHE2 appeared to be more potent than 2-OHE2. Injection of only the vehicle caused no change in gonadotrophin levels. The morning fall of plasma Prl was common in young women as an expression of circadian variation. Although the Prl fall tended to be greater in the 4-OHE2 group, analyses failed to reach statistical significance.
为了研究2-羟基雌二醇（2-OHE2）和4-羟基雌二醇（4-OHE2）对人垂体激素释放的影响，在卵泡期向年轻女性注射了每种类固醇（单次推注500微克）。两种类固醇均导致LH和FSH短暂抑制，随后略有升高。4-OHE2似乎比2-OHE2更有效。仅注射溶媒不会引起促性腺激素水平变化。年轻女性血浆泌乳素在早晨下降是昼夜节律变化的一种表现。尽管4-OHE2组泌乳素下降幅度更大，但分析未达到统计学显著性。
