Ebina T, Saito M
Gan To Kagaku Ryoho. 1984 Jan;11(1):24-35.
Recent reports on the antitumor activity of interferon-gamma were reviewed and compared to a study on interferon-alpha beta. Secondly our results on the antitumor effects of murine IFN-gamma on Meth-A sarcoma in syngeneic BALB/c mice were described in detail. Topical injection of IFN-gamma to the tumor site, Winn neutralization test of IFN-gamma activated spleen cells and adoptive transfer of IFN-gamma activated cells to the tumor site all resulted in positive antitumor effects. Finally, data on clinical trials of natural and recombinant IFNs presented at the 13th International Congress of Chemotherapy were summarized and the development of future IFN research was discussed.
对近期有关γ干扰素抗肿瘤活性的报告进行了综述，并与一项关于αβ干扰素的研究进行了比较。其次，详细描述了我们关于小鼠IFN-γ对同基因BALB/c小鼠体内Meth-A肉瘤抗肿瘤作用的研究结果。向肿瘤部位局部注射IFN-γ、对IFN-γ激活的脾细胞进行Winn中和试验以及将IFN-γ激活的细胞过继转移至肿瘤部位均产生了阳性抗肿瘤效果。最后，总结了在第13届国际化疗大会上发表的关于天然和重组干扰素临床试验的数据，并讨论了未来干扰素研究的发展。
