Vergani C G, Plancher A C, Zuin M, Cattaneo M, Tramaloni C, Maccari S, Roma P, Catapano A L
Eur J Clin Invest. 1984 Feb;14(1):49-54. doi: 10.1111/j.1365-2362.1984.tb00703.x.
A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found.
