Robert A, Böttcher W, Golanska E, Kauffman G L
Gastroenterology. 1984 Apr;86(4):670-4.
The effect of various cytoprotective agents on the thickness of gastric mucus gel layer in rats was studied. It was hypothesized that an increase in the mucus gel layer might be involved in cytoprotection. The results show that this is not the case. Neither prostaglandin E2, 16,16-dimethyl prostaglandin E2, nor mild irritants (20% ethanol, 0.35 M HCl, 20% glucose, 20% mannitol), all given orally, altered the thickness of the mucus gel layer, although these agents were found to be cytoprotective, i.e., inhibiting the formation of gastric mucosal necrotic lesions caused by oral administration of absolute ethanol. The only agents that significantly increased the thickness of the mucus gel layer were a hypertonic solution (4% NaCl) and sodium salicylate. We conclude that if mucus plays a role in cytoprotection, it is not by virtue of an increase in thickness of the gel layer adherent to the gastric mucosa.
研究了各种细胞保护剂对大鼠胃黏液凝胶层厚度的影响。据推测，黏液凝胶层增厚可能与细胞保护作用有关。但结果表明并非如此。口服给予前列腺素E2、16,16-二甲基前列腺素E2以及轻度刺激剂（20%乙醇、0.35M盐酸、20%葡萄糖、20%甘露醇）均未改变黏液凝胶层的厚度，尽管这些药物具有细胞保护作用，即能抑制口服无水乙醇所致胃黏膜坏死病变的形成。唯一能显著增加黏液凝胶层厚度的药物是高渗溶液（4%氯化钠）和水杨酸钠。我们得出结论，如果黏液在细胞保护中起作用，并非是通过增加附着于胃黏膜的凝胶层厚度来实现的。
