人多形核白细胞中12-L-羟基-5,8,10,14-二十碳四烯酸的ω-羟基化作用
Omega-hydroxylation of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid in human polymorphonuclear leukocytes.
作者信息
Wong P Y, Westlund P, Hamberg M, Granström E, Chao P H, Samuelsson B
出版信息
J Biol Chem. 1984 Feb 25;259(4):2683-6.
PMID:6421809
Abstract
Incubation of arachidonic acid or 12-Ls-hydroxy-5,8,10,14-eicosatetraenoic acid with suspensions of human polymorphonuclear leukocytes led to the formation of 12-Ls,20-dihydroxy-5,8,10,14-eicosatetraenoic acid. The structure of the new metabolite was by physical methods and by chemical degradation.
摘要
将花生四烯酸或12-Ls-羟基-5,8,10,14-二十碳四烯酸与人多形核白细胞悬液一起孵育，会导致形成12-Ls,20-二羟基-5,8,10,14-二十碳四烯酸。通过物理方法和化学降解确定了新代谢产物的结构。
Zotero 插件