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通过细菌代谢获得的抗肿瘤疫苗的实验和临床应用结果。

Experimental and clinical results of application of antitumor vaccines obtained by means of bacterial metabolism.

作者信息

Zatula D G

出版信息

Neoplasma. 1984;31(1):65-74.

PMID:6422316
Abstract

By means of metabolic products of the AB-56 strain of Bac. mesentericus it was possible to produce specific antitumor vaccines which both in experimental and clinical conditions proved to have prophylactic and therapeutic effects. 60-100% of the animals prophylactically immunized with these vaccines became resistant to a subsequent injection of living virulent cells, the percentage depending on the number of immunizations. The employment of similar autovaccines in the treatment of relapses and metastases in humans resulted in a 56% five-year survival of patients operated on for gastric cancer, in contrast to a 28% five-year survival of those without any vaccination.

摘要

借助肠系膜芽孢杆菌AB - 56菌株的代谢产物,有可能生产出特异性抗肿瘤疫苗,实验和临床条件均证明其具有预防和治疗作用。用这些疫苗进行预防性免疫的动物中,60% - 100%对随后注射的活毒细胞产生了抗性,该百分比取决于免疫次数。在治疗人类复发和转移时使用类似的自身疫苗,胃癌手术患者的五年生存率为56%,而未进行任何疫苗接种的患者五年生存率为28%。

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