Anticonvulsant activity and embryotoxicity of valproic acid.

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作者信息

Nau H, Löscher W, Schäfer H

出版信息

Neurology. 1984 Mar;34(3):400-1. doi: 10.1212/wnl.34.3.400-b.

DOI:10.1212/wnl.34.3.400-b

PMID:6422322

Abstract

摘要

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Anticonvulsant activity and embryotoxicity of valproic acid.

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引用本文的文献

Species differences in pharmacokinetics and drug teratogenesis.药代动力学和药物致畸作用中的物种差异。

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Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture.药物体外效应的药代动力学方面：血清蛋白结合对丙戊酸和2-烯丙戊酸在培养全胚胎中的浓度及致畸性的影响。

Arch Toxicol. 1986 Apr;58(4):239-42. doi: 10.1007/BF00297113.

Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals.δ2（E）-丙戊酸盐对动物的药理、毒理及神经化学作用。

Pharm Weekbl Sci. 1992 Jun 19;14(3A):139-43. doi: 10.1007/BF01962705.

Differentiation between valproate-induced anticonvulsant effect, teratogenicity and hepatotoxicity. Aspects of species variation, pharmacokinetics, metabolism and implications of structural specificity for the development of alternative antiepileptic agents such as delta 2-valproate.丙戊酸盐诱导的抗惊厥作用、致畸性和肝毒性之间的差异。物种差异、药代动力学、代谢方面以及结构特异性对开发替代抗癫痫药物（如δ2-丙戊酸盐）的影响。

Pharm Weekbl Sci. 1992 Jun 19;14(3A):101-7. doi: 10.1007/BF01962697.

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