Posner J, Sobel R J, Glick S
Isr J Med Sci. 1984 Feb;20(2):113-7.
Serum thyroxine (T4), triiodothyronine (T3), resin uptake of T3 (RT3U), thyroid stimulating hormone (TSH) and TSH response to thyrotropin releasing hormone (TRH) were measured in 92 patients treated with amiodarone for up to 4 years. Two patients developed thyrotoxicosis, while euthyroid hyperthyroxinemia occurred in 29 (32%). Hypothyroidism was diagnosed in 11 patients (12%), and a further 11 had tests consistent with a "failing thyroid." Of 39 patients with normal values of T4, 15 had abnormal responses to TRH. Of the 92 patients, 24 were tested before administration of amiodarone and then sequentially; alterations in thyroid function were frequent within the first 3 months. A scheme is proposed for early recognition of disturbed thyroid function due to amiodarone.
对92例接受胺碘酮治疗长达4年的患者测定了血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、T3树脂摄取率（RT3U）、促甲状腺激素（TSH）以及TSH对促甲状腺激素释放激素（TRH）的反应。2例患者发生甲状腺毒症，29例（32%）出现甲状腺功能正常的甲状腺素血症。11例患者（12%）被诊断为甲状腺功能减退，另有11例的检查结果符合“甲状腺功能减退”。在T4值正常的39例患者中，15例对TRH的反应异常。92例患者中，24例在服用胺碘酮前及之后进行了连续检测；甲状腺功能在前3个月内频繁发生改变。提出了一个早期识别胺碘酮所致甲状腺功能紊乱的方案。
