麻醉猫低碳酸血症期间的通气性二氧化碳反应。

Ventilatory CO2 responses during hypocapnia in anesthetized cats.

作者信息

Yamashiro S M, Ghazanshahi S

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):678-80. doi: 10.1152/jappl.1984.56.3.678.

DOI:10.1152/jappl.1984.56.3.678

Abstract

CO2 response curves were measured in six anesthetized cats under open-loop conditions in both hyperoxia and hypoxia. Markedly nonlinear characteristics were observed with CO2 response slopes below the normal operating level almost three times that above the normal operating level. In all animals, complete apnea was observed when CO2 was reduced sufficiently. The zero ventilation intercept averaged 23.5 +/- 5.6 (SD) Torr in hyperoxia (arterial PO2 greater than 400 Torr) and 21.0 +/- 5.4 Torr in hypoxia (arterial PO2 = 52.7 Torr). These results suggest that an increased tendency for periodic breathing in hypocapnia could be due to the higher CO2 response slope.

摘要

在高氧和低氧的开环条件下，对6只麻醉猫测量了二氧化碳反应曲线。观察到明显的非线性特征，正常操作水平以下的二氧化碳反应斜率几乎是正常操作水平以上的三倍。在所有动物中，当二氧化碳充分降低时均观察到完全呼吸暂停。在高氧（动脉血氧分压大于400托）时，零通气截距平均为23.5±5.6（标准差）托，在低氧（动脉血氧分压=52.7托）时为21.0±5.4托。这些结果表明，低碳酸血症时周期性呼吸倾向增加可能是由于较高的二氧化碳反应斜率所致。