克罗恩病中的血小板动力学

Platelet kinetics in Crohn's disease.

作者信息

Bremer G, Jacobi E, Miller B, Ehms H, Strohmeyer G

出版信息

Klin Wochenschr. 1978 Apr 1;56(7):365-7. doi: 10.1007/BF01477398.

Abstract

The pathogenesis of thrombocytosis in Crohn's disease was analized in ten non-treated patients using the 51Cr labelling method. The data obtained were compared to those taken from a control group. Besides platelet survival time, platelet turnover, surface radioactivity, platelet adhesiveness and morphological aspects of bone marrow were investigated. Platelet survival time in patients with Crohn's disease proved to be significantly shortened (p less than 0.001), whereas platelet turnover appeared augmented. No additional radioactivity is encountered from the organs scanned. The relative platelet adhesiveness is diminished while thrombocytopoesis in bone marrow is augmented.

摘要

采用51Cr标记法对10例未经治疗的克罗恩病患者血小板增多症的发病机制进行了分析。将获得的数据与对照组的数据进行了比较。除了血小板存活时间外，还研究了血小板周转率、表面放射性、血小板黏附性和骨髓的形态学特征。结果表明，克罗恩病患者的血小板存活时间显著缩短（p<0.001），而血小板周转率则有所增加。扫描的器官未发现额外的放射性。血小板相对黏附性降低，而骨髓中的血小板生成增加。