Rosner F, Zarrabi M H, Benach J L, Habicht G S
Am J Med. 1984 Apr;76(4):696-701. doi: 10.1016/0002-9343(84)90298-5.
Since 1957, there have been 22 reported cases of human babesiosis in splenectomized persons, representing about one third of all clinical human babesiosis. Splenectomy had been performed one month to 36 years (mean 8.7 years, median 6.0 years) earlier for a variety of reasons. Four of the seven European cases were from Babesia divergens whereas 12 of the 15 United States cases were from B. microti. Most of the 22 patients had moderate to severe clinical disease including hemolytic anemia, yet all but six recovered. Three patients had transfusion-acquired babesiosis. Treatments employed included the use of chloroquine, quinine, pyrimethamine, pentamidine, clindamycin, dialysis, and exchange transfusion. Splenectomized and/or otherwise immunocompromised hosts should be advised to avoid visiting endemic areas for babesiosis such as Nantucket Island or Martha's Vineyard in Massachusetts and Shelter Island and other parts of Long Island, New York. Babesiosis must be considered as one of the not uncommon organisms responsible for the postsplenectomy sepsis syndrome and one for which there is no current prophylaxis.
自1957年以来，已有22例脾切除患者发生人类巴贝斯虫病的报告病例，约占所有临床人类巴贝斯虫病的三分之一。脾切除术因各种原因在1个月至36年（平均8.7年，中位数6.0年）前进行。7例欧洲病例中有4例感染的是分歧巴贝斯虫，而15例美国病例中有12例感染的是微小巴贝斯虫。这22例患者中大多数有中度至重度临床疾病，包括溶血性贫血，但除6例之外均康复。3例患者发生输血获得性巴贝斯虫病。采用的治疗方法包括使用氯喹、奎宁、乙胺嘧啶、喷他脒、克林霉素、透析和换血疗法。应建议脾切除和/或其他免疫功能低下的宿主避免前往巴贝斯虫病流行地区，如马萨诸塞州的楠塔基特岛或玛莎葡萄园岛以及纽约长岛的谢尔特岛和其他地区。巴贝斯虫病必须被视为导致脾切除术后败血症综合征的常见病原体之一，且目前尚无针对该病的预防措施。
