Mostefa-Kara M, Blin D, Langlet F, Mouly A, Goudard A, Montiès J R
Arch Mal Coeur Vaiss. 1984 Feb;77(2):161-6.
Forty seven bioprostheses were used for mitral valve replacement between January 1975 and June 1980, with no operative mortality, in children under 19 years of age. This study was undertaken to evaluate the medium and longterm outcome of 43 patients followed up for at least 2 years. The late mortality was higher in children under 13 years of age (11.1% per patient/year) than in older children (3% per patient/year). The incidence of reoperation for deterioration of the bioprosthesis was 5,5% per patient/year. The actuarial longevity of bioprostheses without any complications was 48 +/- 16% at 5 years. After a review of the literature, the authors discuss their present therapeutic attitude: whenever possible, mitral valvuloplasty is the operation of choice, but when valve replacement is necessary, two criteria must be considered: the age of the patient and conditions of follow up. If medical follow-up facilities are good: mechanical prostheses are preferred in patients under 13 years of age: after puberty especially in girls, the bioprosthesis is the valve of choice. If medical follow-up facilities are poor: the valve of choice is a bioprosthesis at all ages because of the risk of thromboembolism and the relatively slow clinical aggravation in cases of bioprosthetic deterioration.
1975年1月至1980年6月期间,47个生物瓣膜用于19岁以下儿童的二尖瓣置换术,无手术死亡病例。本研究旨在评估43例随访至少2年患者的中长期结果。13岁以下儿童的晚期死亡率(每年每位患者11.1%)高于年龄较大儿童(每年每位患者3%)。生物瓣膜恶化再次手术的发生率为每年每位患者5.5%。无任何并发症的生物瓣膜5年时的预期寿命为48±16%。在回顾文献后,作者讨论了他们目前的治疗态度:只要有可能,二尖瓣成形术是首选手术,但当需要瓣膜置换时,必须考虑两个标准:患者年龄和随访条件。如果医疗随访设施良好:13岁以下患者首选机械瓣膜;青春期后,尤其是女孩,生物瓣膜是首选瓣膜。如果医疗随访设施较差:由于血栓栓塞风险以及生物瓣膜恶化时临床病情进展相对缓慢,各年龄段首选瓣膜均为生物瓣膜。