Even P, Nicolaidis S
C R Acad Sci III. 1984;298(9):261-6.
The " Metabolisme de Fond" (MF) is defined as the energy expenditure of the whole body cells, except for the energy devoted to the locomotor activity. The continuous measurement of the MF is performed in the free moving rat using a computer-controlled open circuitry calorimeter. This system provides simultaneous measurement of the metabolic parameters (oxygen, carbon-dioxide, respiratory quotient) as well as the quantification of the behavioral parameters (food intake, locomotor activity, sleep). The measurement of the MF is based on the calculation of the slope of the curve linking the relative changes in the intensity of respectively locomotor activity and total metabolism. Such a computation of the MF requires the precise analysis and the subsequent mathematical correction of the physical phenomena occurring in an open circuitry calorimeter. Indeed the instantaneous electrical signal of locomotor activity is recorded before the delayed and distorted corresponding increase in the energetic metabolism which must be corrected. In conclusion, the method described here allows the direct determination of quick MF modifications in the freely behaving rat.
“基础代谢”（MF）被定义为全身细胞的能量消耗，但不包括用于运动活动的能量。使用计算机控制的开放式热量计对自由活动的大鼠进行MF的连续测量。该系统可同时测量代谢参数（氧气、二氧化碳、呼吸商）以及量化行为参数（食物摄入量、运动活动、睡眠）。MF的测量基于连接运动活动强度和总代谢的相对变化曲线的斜率计算。这种MF的计算需要对开放式热量计中发生的物理现象进行精确分析并随后进行数学校正。实际上，运动活动的瞬时电信号在能量代谢相应的延迟和失真增加之前被记录下来，必须对其进行校正。总之，这里描述的方法可以直接测定自由行为大鼠中MF的快速变化。
