聚乙烯膦酸盐和乙烷羟基二膦酸盐对异位骨矿化的影响。
Effect of polyvinyl phosphonates and ethane hydroxy diphosphonate on mineralization of ectopic bone.
作者信息
Rath N C, Dimitrijevich S, Anbar M
出版信息
Chem Biol Interact. 1984 Mar;48(3):339-47. doi: 10.1016/0009-2797(84)90144-3.
The effects of polymeric polyphosphonate and of ethane hydroxydiphosphonate on the development of ectopic bone were compared at different stages of bone development. The diphosphonate affected bone development at different stages, as reflected by alkaline phosphatase and aryl sulphatase activities, as well as by the creation of calcium ions by bone and on its readiness to undergo isotopic exchange. The polymeric polyphosphonate (mol. wt., 3500-8000), on the other hand, did not exhibit any of these effects, although it did inhibit the activity of the enzymes in vitro to an extent comparable with that of the diphosphonate. The results corroborate the assumption that the effects of polymeric polyphosphonates on hard tissues are confined to the extracellular space while the effects of diphosphonates on bone development are due to intracellular activity and not to sequestering of extracellular calcium.
在骨骼发育的不同阶段，比较了聚合聚膦酸盐和乙烷羟基二膦酸盐对异位骨发育的影响。二膦酸盐在不同阶段影响骨骼发育，这通过碱性磷酸酶和芳基硫酸酯酶的活性以及骨骼产生钙离子及其进行同位素交换的准备情况得以体现。另一方面，聚合聚膦酸盐（分子量为3500 - 8000）虽然在体外确实能在一定程度上抑制酶的活性，且抑制程度与二膦酸盐相当，但并未表现出这些影响中的任何一种。这些结果证实了这样一种假设，即聚合聚膦酸盐对硬组织的影响局限于细胞外空间，而二膦酸盐对骨骼发育的影响是由于细胞内活性，而非细胞外钙的螯合作用。
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