Phenekos C, Karamerou A, Pipis P, Constantoulakis M, Lasaridis J, Detsi S, Politou K
Clin Endocrinol (Oxf). 1984 Apr;20(4):445-50. doi: 10.1111/j.1365-2265.1984.tb03440.x.
Thyroid function was evaluated in 20 patients aged 8-30 years who were suffering from homozygous beta-thalassaemia. All patients have been receiving frequent blood transfusions and treated for the resulting transfusional iron overload with intramuscular injections of Desferrioxamine. Total thyroxine (T4), T3-uptake, total triiodothyronine (T3), and reverse triiodothyronine (rT3) were measured. In addition a standard TRH stimulation test was performed and blood samples were checked for the presence of thyroid antibodies. It was found that total T4 was significantly lower in the patients than in the controls. Total T3 and rT3 levels were similar in both patients and controls and all patients were negative for thyroid antibodies. T3 uptake in the patients was also statistically different from the controls resulting in significantly lower free thyroxine index (FT1). Basal TSH values were not different from the controls but the TSH increase following TRH stimulation was significantly higher in the patients suggesting, together with the low total T4 and FTI, a state of compensated hypothyroidism.
对20名年龄在8至30岁、患有纯合子β地中海贫血的患者进行了甲状腺功能评估。所有患者均频繁接受输血治疗，并通过肌肉注射去铁胺治疗由此导致的输血性铁过载。测量了总甲状腺素（T4）、T3摄取率、总三碘甲状腺原氨酸（T3）和反三碘甲状腺原氨酸（rT3）。此外，进行了标准的促甲状腺激素释放激素（TRH）刺激试验，并检查血样中是否存在甲状腺抗体。结果发现，患者的总T4显著低于对照组。患者和对照组的总T3和rT3水平相似，所有患者的甲状腺抗体均为阴性。患者的T3摄取率与对照组也存在统计学差异，导致游离甲状腺素指数（FTI）显著降低。基础促甲状腺激素（TSH）值与对照组无差异，但TRH刺激后患者的TSH升高显著高于对照组，这与低总T4和FTI一起提示存在代偿性甲状腺功能减退状态。
