Skevakis L, Frasch C E, Zahradnik J M, Dolin R
J Infect Dis. 1984 Mar;149(3):387-96. doi: 10.1093/infdis/149.3.387.
Bactericidal and enzyme-linked immunosorbent assays were used to determine the immunoglobulin classes responsible for group- and type-specific immunity to Neisseria meningitidis among healthy, unvaccinated individuals and persons who received group-B N meningitidis polysaccharide-serotype-2 protein vaccine. Bactericidal antibodies to the group B polysaccharide were primarily IgM; only a few individuals had both IgM and IgG antibodies. IgG bactericidal antibodies were detected only in those individuals with high IgM-antibody levels to group B meningococci. Increased levels of bactericidal antibodies to the group-B polysaccharide were infrequently found in vaccinees, possibly because of high prevaccination bactericidal-antibody levels. Bactericidal antibodies to the group-C polysaccharide were IgM, IgG, or both. Vaccine-induced antibodies to lipopolysaccharide were not bactericidal for a group-C serotype-2 strain with the lipopolysaccharide immunotype of the vaccine strain.
采用杀菌试验和酶联免疫吸附试验，以确定健康未接种人群以及接种B群脑膜炎奈瑟菌2型多糖-蛋白疫苗的人群中，针对脑膜炎奈瑟菌群特异性和型特异性免疫的免疫球蛋白类别。针对B群多糖的杀菌抗体主要为IgM；仅有少数个体同时具有IgM和IgG抗体。仅在那些对B群脑膜炎球菌IgM抗体水平较高的个体中检测到IgG杀菌抗体。疫苗接种者中很少发现针对B群多糖的杀菌抗体水平升高，这可能是由于接种前杀菌抗体水平较高所致。针对C群多糖的杀菌抗体为IgM、IgG或两者皆有。疫苗诱导产生的针对脂多糖的抗体，对具有疫苗株脂多糖免疫型的C群2型菌株无杀菌作用。
