Senoo Y, Murakami T, Kawakami S, Teramoto S
Jpn Circ J. 1984 Apr;48(4):414-20. doi: 10.1253/jcj.48.414.
For the last 20 years, vasodilator drugs have been used for the therapy of congestive heart failure. During this period, there has been increasing interest in the treatment of congestive heart failure. Vasodilators are divided into one which reduces preload, another which reduces after-load and the last which has both effects. Changes in cardiac output causes changes in distribution of cardiac output to each organ. Therefore, after vasodilators injection, changes in systemic distribution of blood flow should not be equal in each organ. In this report, changes in systemic distribution of cardiac output after vasodilator injection are discussed. Systemic distribution of blood flow in normal circulation differs from that in abnormal circulation. In this report, effects of vasodilators on systemic distribution of cardiac output in the state of experimentally created heart failure are discussed.
在过去20年中，血管扩张剂一直用于治疗充血性心力衰竭。在此期间，人们对充血性心力衰竭的治疗兴趣日益浓厚。血管扩张剂分为降低前负荷的一类、降低后负荷的一类以及兼具两者作用的一类。心输出量的变化会导致心输出量在各器官间分布的改变。因此，注射血管扩张剂后，各器官血流的全身分布变化不应相同。在本报告中，讨论了注射血管扩张剂后心输出量的全身分布变化。正常循环中血流的全身分布与异常循环中的不同。在本报告中，讨论了血管扩张剂对实验性心力衰竭状态下心输出量全身分布的影响。
