在自发性小发作样癫痫大鼠中，拟γ-氨基丁酸（GABA）药物对棘波和慢波放电的增强作用。
Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mal-like epilepsy.
作者信息
Vergnes M, Marescaux C, Micheletti G, Depaulis A, Rumbach L, Warter J M
出版信息
Neurosci Lett. 1984 Jan 27;44(1):91-4. doi: 10.1016/0304-3940(84)90226-x.
Certain Wistar rats from our laboratory colony present genetically determined seizures similar to human petit-mal absences. Muscimol, THIP and L-baclofen, agonists of GABA receptors, and gamma-vinyl GABA (GVG), an inhibitor of GABA degradation, enhanced the duration of spontaneous petit-mal-like seizures in a dose-dependent fashion. These findings raise questions as to the role of GABAergic neurotransmission in the occurrence of this type of spontaneous spike and wave discharges.
我们实验室种群中的某些Wistar大鼠表现出与人类小发作失神相似的遗传性癫痫发作。GABA受体激动剂蝇蕈醇、THIP和L-巴氯芬，以及GABA降解抑制剂γ-乙烯基GABA（GVG），以剂量依赖性方式延长了自发性小发作样癫痫发作的持续时间。这些发现引发了关于GABA能神经传递在这种自发性棘波和慢波放电发生中作用的疑问。
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