Lamont S J, Smyth J R
Poult Sci. 1984 Mar;63(3):436-9. doi: 10.3382/ps.0630436.
Studies were conducted to compare the antibody production of the Delayed Amelanotic (DAM) line of chickens with that of the line from which it originated, the Brown line (BR), and a distantly related environmental control, the Light Brown Leghorn (LBL). Total agglutinating antibody titers following immunization with sheep red blood cells (SRBC) or Brucella abortus (BA), were determined at 4, 6, 8, 10, 12, 16, and 20 weeks. The SRBC titers of DAM line birds were significantly higher than those of LBL birds but not BR birds at young ages (4 to 8 weeks) and at 20 weeks. The BA titers of DAM and BR lines were significantly higher than those of the LBL line at 4 and 6 weeks. We conclude that the DAM line exhibits hyperreactivity in B-cell function, which may be related to the line-associated pigmentation destruction. These studies also confirm that age is an important factor in making comparisons of antibody production between different genetic stocks.
开展了多项研究，以比较迟发性无黑色素（DAM）品系鸡与该品系的起源品系——棕色品系（BR），以及一个远缘环境对照品系——浅褐来航鸡（LBL）的抗体产生情况。在用绵羊红细胞（SRBC）或流产布鲁氏菌（BA）免疫后，于第4、6、8、10、12、16和20周测定总凝集抗体滴度。在幼龄期（4至8周）及20周时，DAM品系鸡的SRBC滴度显著高于LBL品系鸡，但不高于BR品系鸡。在第4和6周时，DAM品系和BR品系的BA滴度显著高于LBL品系。我们得出结论，DAM品系在B细胞功能方面表现出高反应性，这可能与该品系相关的色素沉着破坏有关。这些研究还证实，年龄是比较不同遗传品系间抗体产生情况的一个重要因素。
