Mukai M, Yamazaki Y, Amano H, Hiura T, Oda S, Namiki S, Nakajima K, Nagao K
Gan To Kagaku Ryoho. 1984 May;11(5):1071-7.
OMF treatment consisting of perifocal administration of OK-432 associated with MMC and 5-FU was applied for 37 lesions of 35 cases including 2 with multiple cancer. The results obtained were as follows lesions. Macroscopical efficacy was rated as "good" in 12 lesions (32.4%), "fair" in 24 lesions (64.9%) and "poor" in 1 case. Histological efficacy was assessed as "++" for 10 lesions (27%), and "+" for 16 lesions (43.2%). Taking "+" or higher histologically as "effective", the efficacy rate was approximately 71%. Efficacy rate for metastatic lymph nodes was approximately 61% in patients who underwent a curative operation. Patients who received non-curative operation showed a certain efficacy to some extent. Twenty-one cases were judged as "S2" at operation. 11 cases as "se", and another 10 cases as 2 cases of "ss beta" and 8 cases of "pm" Histologically . Seven cases of "pm" were considered either as "good" or Histological efficacy as "++" in terms of macroscopical efficacy.
对35例患者的37个病变（包括2例多发癌）采用丝裂霉素（MMC）、氟尿嘧啶（5 - FU）联合沙培林病灶周围注射的口腔颌面外科（OMF）治疗方法。结果如下：肉眼疗效评定为“好”的有12个病变（32.4%），“一般”的有24个病变（64.9%），“差”的有1个病变。组织学疗效评定为“++”的有10个病变（27%），“+”的有16个病变（43.2%）。以组织学“+”及以上为“有效”，有效率约为71%。接受根治性手术患者的转移淋巴结有效率约为61%。接受非根治性手术的患者也有一定程度的疗效。手术时21例判定为“S2”，11例为“se”，另外10例为2例“ss beta”和8例“pm”。组织学上，7例“pm”在肉眼疗效方面被认为“好”或组织学疗效为“++”。
