Mountié J, Rivera F, Goudonnet H, Escousse A, Truchot R C
Arch Latinoam Nutr. 1983 Sep;33(3):664-78.
The influence of two carbamine pesticides i.e., manebe and carbaryl upon the hepatic microsomal enzymes induction in the rat was studied. Both substances, when administered by themselves, affect only slightly liver weight, P 450 cytochrome rates and bilirubin glucuronosyltransferase, in the microsome fraction of the hepatic homogenate. It seems, however, that carbaryl is involved in producing a slight induction, whereas manebe acts inversely. Yet, manebe changes largely the induction effects of phenobarbital when associated with the latter. In the animal treated simultaneously with manebe and phenobarbital, the increase in the rate of hepatic microsomal P 450 cytochrome as well as the variations in the distribution of fatty acids in phospholipids, are significantly lower than in the animal solely treated with phenobarbital.
研究了两种氨基甲酸盐农药（即代森锰和西维因）对大鼠肝微粒体酶诱导的影响。这两种物质单独给药时，对肝匀浆微粒体部分的肝脏重量、细胞色素P450速率和胆红素葡萄糖醛酸转移酶的影响很小。然而，西维因似乎参与了轻微的诱导作用，而代森锰则起相反作用。然而，代森锰与苯巴比妥联合使用时，会大大改变苯巴比妥的诱导作用。在同时用代森锰和苯巴比妥处理的动物中，肝微粒体细胞色素P450速率的增加以及磷脂中脂肪酸分布的变化，明显低于仅用苯巴比妥处理的动物。
