Kinetic studies of the activation of factor X by factors IXa and VIII:C in the absence of thrombin.
作者信息
Neal G G, Esnouf M P
出版信息
Br J Haematol. 1984 May;57(1):123-31. doi: 10.1111/j.1365-2141.1984.tb02872.x.
Abstract
The activation of factor X by the components of the intrinsic coagulation pathway has been studied using a preparation of bovine factor VIII which did not require 'activation' with thrombin prior to its participation in the reaction. Measurements of the kinetic parameters indicated that factor VIII:C stimulated the formation of factor Xa via a 170-fold increase in the Vmax; factor VIII:C had little effect on the Km for factor X.
摘要
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