Byers S W, Glover T D
J Reprod Fertil. 1984 May;71(1):23-31. doi: 10.1530/jrf.0.0710023.
The testes of rams were insulated for 28 days. After 28 days typical degenerative changes occurred in the tubular compartment of the testis. Spermatozoa, spermatids and, in many tubules, spermatocytes were absent. A pronounced dilatation of the testicular lymph vessels was noted, and a morphometric study indicated that the volume fraction occupied by Leydig cells was greater than in controls. A serial bleeding regimen showed that peripheral plasma concentrations of FSH were elevated and of testosterone were usually reduced after scrotal insulation. Although mean testosterone levels were unchanged after 7 days of treatment, there were more hormone episodes, each of significantly reduced amplitude. LH values were elevated at this time and there was an increase in the number and amplitude of LH episodes. After 14 days of scrotal insulation, mean and basal levels of testosterone were significantly reduced, and episodes of secretion were much smaller in amplitude. Mean LH values were elevated and each secretory episode was of significantly greater amplitude than in control blood. These results show that the testes of scrotally insulated rams are relatively insensitive to endogenous LH and that this treatment affects cells within the seminiferous tubule and those in the interstitial compartment.
对公羊的睾丸进行了28天的隔离处理。28天后，睾丸的曲细精管部分出现了典型的退行性变化。精子、精细胞以及在许多曲细精管中的精母细胞均消失。观察到睾丸淋巴管有明显扩张，形态计量学研究表明，间质细胞所占的体积分数高于对照组。连续放血方案显示，阴囊隔离后，外周血中促卵泡激素（FSH）浓度升高，睾酮浓度通常降低。虽然治疗7天后睾酮的平均水平未变，但激素分泌峰次数增多，且每次分泌峰的幅度显著降低。此时促黄体生成素（LH）值升高，LH分泌峰的数量和幅度增加。阴囊隔离14天后，睾酮的平均水平和基础水平显著降低，分泌峰的幅度也小得多。LH的平均水平升高，每次分泌峰的幅度明显大于对照血液中的分泌峰。这些结果表明，阴囊隔离的公羊睾丸对内源性LH相对不敏感，这种处理会影响生精小管内的细胞以及间质中的细胞。
