Peters A R
Vet Rec. 1984 Apr 28;114(17):418-21. doi: 10.1136/vr.114.17.418.
Thirteen cows received 0.75 mg tiaprost by subcutaneous injection during the mid-luteal phase of the ovarian cycle. Twelve underwent rapid luteolytic and continued to cycle normally as determined by milk or plasma progesterone concentrations. The other cow underwent only a transient decrease in progesterone concentrations. A further 15 cows received either a subcutaneous osmotic mini-pump containing 30 mg tiaprost , calibrated to release 0.75 mg over a 24 hour period (group 1); a subcutaneous injection of 0.375 mg tiaprost (group 2), or a subcutaneous injection of 0.375 mg tiaprost plus the osmotic mini pump (group 3). Treatment caused luteolysis in zero and one cows in groups 1 and 3 respectively. However all six cows in group 2 underwent rapid luteolysis. Although the standard therapeutic dose of tiaprost (0.75 mg) appears to be a highly effective luteolytic agent it is concluded that there may be scope for development of longer acting formulations of this compound.
13头母牛在卵巢周期的黄体中期接受皮下注射0.75毫克噻前列素。12头母牛发生快速黄体溶解，并根据牛奶或血浆孕酮浓度测定继续正常发情周期。另一头母牛仅出现孕酮浓度短暂下降。另有15头母牛接受以下处理：皮下植入含30毫克噻前列素的渗透微型泵，校准后在24小时内释放0.75毫克（第1组）；皮下注射0.375毫克噻前列素（第2组）；或皮下注射0.375毫克噻前列素加渗透微型泵（第3组）。第1组和第3组分别有0头和1头母牛因治疗导致黄体溶解。然而，第2组的所有6头母牛均发生快速黄体溶解。虽然噻前列素的标准治疗剂量（0.75毫克）似乎是一种高效的黄体溶解剂，但得出的结论是，该化合物可能有开发长效制剂的空间。
