Auwerx J, Demedts M, Bouillon R
Acta Endocrinol (Copenh). 1984 Jun;106(2):215-8. doi: 10.1530/acta.0.1060215.
Changes in calcium concentration were induced by an infusion of disodium-EDTA or calcium in 2 members of a family suffering from hypocalciuric hypercalcaemia ( FHH ) associated with interstitial lung disease. These changes in calcium demonstrated an inverse linear relationship with the changes in serum parathyroid hormone (PTH). Infusion of EDTA in control subjects and in patients with an adenoma or hyperplasia of the parathyroid glands also showed inverse relationships between calcium and PTH. The correlation between serum calcium and serum PTH was significant over the range observed during the induced hypo- and/or hypercalcaemia in controls and in patients with FHH or adenoma. The regressions were, however, shifted relative to each other: in comparison with controls, the FHH was displaced upwards and to the right, although not as far as the adenomas. These findings suggest the existence of an elevated set point for extracellular calcium (or calciostat ) in FHH .
在一个患有与间质性肺病相关的低钙血症性高钙血症（FHH）的家族中的两名成员中，通过输注乙二胺四乙酸二钠或钙来诱导钙浓度变化。这些钙变化与血清甲状旁腺激素（PTH）变化呈反线性关系。在对照受试者以及患有甲状旁腺腺瘤或增生的患者中输注乙二胺四乙酸也显示钙与PTH之间存在反关系。在对照以及患有FHH或腺瘤的患者中，在诱导的低钙血症和/或高钙血症期间观察到的范围内，血清钙与血清PTH之间的相关性显著。然而，回归线相互偏移：与对照相比，FHH向上和向右移位，尽管不如腺瘤移位得那么远。这些发现表明FHH中细胞外钙（或钙稳定）的设定点升高。
