司来吉兰（丙炔苯丙胺）的给药方案与血小板单胺氧化酶活性。

Dose regimen of deprenyl (selegiline) and platelet MAO activities.

作者信息

Oreland L, Johansson F, Ekstedt J

出版信息

Acta Neurol Scand Suppl. 1983;95:87-9. doi: 10.1111/j.1600-0404.1983.tb01519.x.

DOI:10.1111/j.1600-0404.1983.tb01519.x

Abstract

The effect of various doses of deprenyl on thrombocyte MAO activity in parkinsonian patients has been studied. It is suggested that individual differences in the degree of inhibition are due to differences in the metabolic rate of deprenyl. The recovery of thrombocyte MAO activity was linear at a rate of approximately 10% per day. The linearity of the recovery suggests that the disappearance of the population of thrombocytes is selected with respect to age.

摘要

研究了不同剂量的司来吉兰对帕金森病患者血小板单胺氧化酶活性的影响。有人认为抑制程度的个体差异是由于司来吉兰代谢率的差异所致。血小板单胺氧化酶活性的恢复呈线性，每天约以10%的速率恢复。恢复的线性表明血小板群体的消失是按年龄选择的。