酮替芬治疗支气管哮喘的长期试验
Long term trial of ketotifen in bronchial asthma.
作者信息
Podleski W K, Zelenak T M, Schmidt J L
出版信息
Ann Allergy. 1984 Jun;52(6):406-10.
PMID:6428279
Abstract
Ketotifen in a dose of 1 mg p.o. q 12 h was compared with placebo in a double-blind, twelve month parallel group trial in 17 randomly selected patients with bronchial asthma. Among 13 patients treated with ketotifen, nine have been classified as responders and four as non-responders. Responders were young and teenaged individuals, athletically oriented, with moderate asthma. It is our impression that ketotifen offers a new therapeutic dimension in the prophylaxis of bronchial asthma.
摘要
在一项针对17名随机选取的支气管哮喘患者的双盲、为期12个月的平行组试验中，将剂量为1毫克口服、每12小时一次的酮替芬与安慰剂进行了比较。在13名接受酮替芬治疗的患者中，9名被归类为有反应者，4名被归类为无反应者。有反应者为年轻人和青少年，以运动为导向，患有中度哮喘。我们的印象是，酮替芬在支气管哮喘的预防方面提供了一个新的治疗维度。
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引用本文的文献
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Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders.酮替芬。对其药效学和药代动力学特性以及在哮喘和过敏性疾病中的治疗用途的综述。
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