Wagner W H, Silberman H
Arch Surg. 1984 Jul;119(7):809-10. doi: 10.1001/archsurg.1984.01390190051011.
Protein malnutrition has been directly related to impaired immunocompetence. An experimental protocol was designed to determine the efficacy of a lipid-based system of total parenteral nutrition (TPN) in restoring immunocompetence in nutritionally depleted subjects. Thirty rats sensitized to PPD were made anergic by the oral administration of a protein-free diet. Nutritional repletion was instituted with either a complete oral diet or lipid-based TPN. The two groups of animals did not differ significantly in the time required to regain positive skin test reactivity or in the weight gained during the repletion period. The lipid-based system of TPN was comparable to the complete oral diet in reversing the anergy of protein malnutrition.
蛋白质营养不良与免疫能力受损直接相关。设计了一项实验方案，以确定基于脂质的全胃肠外营养（TPN）系统在恢复营养缺乏受试者免疫能力方面的功效。30只对结核菌素纯蛋白衍生物（PPD）致敏的大鼠通过口服无蛋白饮食而变得无反应。分别用完全口服饮食或基于脂质的TPN进行营养补充。两组动物在恢复阳性皮肤试验反应性所需时间或补充期内体重增加方面无显著差异。基于脂质的TPN系统在逆转蛋白质营养不良的无反应状态方面与完全口服饮食相当。
