卡波西肉瘤与自身免疫性血小板减少症。

Kaposi's sarcoma and autoimmune thrombocytopenia.

作者信息

Modlin R L, Kempf R A, Mitchell M S, Taylor C R, Davis C R, Rea T H

出版信息

Cancer Invest. 1984;2(2):97-101. doi: 10.3109/07357908409020292.

DOI:10.3109/07357908409020292

Abstract

Outbreaks of Kaposi's sarcoma, opportunistic infections, and autoimmune thrombocytopenia among homosexual men have recently been described. We report here a case with the combination of Kaposi's sarcoma and autoimmune thrombocytopenia. Our patient presented with Kaposi's sarcoma limited to the integument and autoimmune thrombocytopenia diagnosed by elevated platelet bound IgG. Characteristics of immunosuppression included lymphocytopenia and a reversed blood helper:suppressor T lymphocyte ratio. Immunohistochemical evaluation of skin biopsy specimens revealed tumor cells to contain Factor VIII-related antigen (a vascular endothelial cell marker). In addition some tumor cells stained positively with a monoclonal antibody directed against a cytomegalovirus antigen.

摘要

最近已报道了同性恋男性中卡波西肉瘤、机会性感染和自身免疫性血小板减少症的暴发。我们在此报告1例合并卡波西肉瘤和自身免疫性血小板减少症的病例。我们的患者表现为仅累及皮肤的卡波西肉瘤和因血小板结合IgG升高而诊断的自身免疫性血小板减少症。免疫抑制的特征包括淋巴细胞减少和血液辅助性T淋巴细胞与抑制性T淋巴细胞比例倒置。皮肤活检标本的免疫组织化学评估显示肿瘤细胞含有VIII因子相关抗原（一种血管内皮细胞标志物）。此外，一些肿瘤细胞用针对巨细胞病毒抗原的单克隆抗体染色呈阳性。