Post danazol amenorrhoea.

Four women out of 242 experienced amenorrhoea in excess of 6 months duration following danazol treatment. Two of these exhibited an unusual monotropic rise of FSH into the post menopausal range for 4-5 months following the end of therapy. This was associated with an excessive response to GnRH injection. The mechanism of this temporary FSH rise is unknown. A causal association of the amenorrhoea and monotropic FSH rise following danazol therapy is unproven but seems likely.