特发性血小板减少性紫癜患者脾淋巴细胞在体外自发产生人γ干扰素。
Spontaneous production of human gamma interferon in vitro by splenic lymphocytes of patients with idiopathic thrombocytopenic purpura.
作者信息
Hu Y W, Xue G X, Tan Y H
出版信息
Clin Exp Immunol. 1984 May;56(2):459-63.
Lymphocytes derived from spleens of traffic trauma victims do not appear to produce human interferon (IFN) activity, spontaneously, in vitro. However, lymphocytes derived from spleens of four ITP patients were found to produce significant amounts of human IFN activity. The IFN activity produced by the splenic lymphocytes of ITP patients was neutralized by anti-gamma-IFN antisera but not anti-alpha or anti-beta antisera. The IFN activity was found to be unstable at pH 2.0 and at 56 degrees C. Thus the human IFN activity of splenic lymphocytes is characterized as human gamma-IFN. No human IFN activity was detectable in the serum of the ITP patients and it is not known whether the splenic lymphocytes of ITP patients also produce human gamma-IFN in vivo. The observations suggest that conditions prevail in the ITP state that predispose the splenic lymphocytes to produce human gamma-IFN without stimulation by exogenously added inducer.
交通创伤受害者脾脏来源的淋巴细胞在体外似乎不会自发产生人干扰素（IFN）活性。然而，发现来自4例免疫性血小板减少性紫癜（ITP）患者脾脏的淋巴细胞能产生大量人IFN活性。ITP患者脾脏淋巴细胞产生的IFN活性可被抗γ-IFN抗血清中和，但不能被抗α或抗β抗血清中和。发现该IFN活性在pH 2.0和56℃时不稳定。因此，脾脏淋巴细胞的人IFN活性被鉴定为人γ-IFN。在ITP患者血清中未检测到任何人类IFN活性，并且尚不清楚ITP患者的脾脏淋巴细胞在体内是否也产生人γ-IFN。这些观察结果表明，在ITP状态下存在一些条件，使脾脏淋巴细胞在没有外源性添加诱导剂刺激的情况下易于产生人γ-IFN。
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