一种测量气管黏液凝胶层厚度变化以指示速发型超敏反应的方法。

A method for measuring changes in tracheal mucus gel layer thickness as an indication of an immediate hypersensitivity response.

作者信息

Yanni J M, Smith W L, Callaham E M, Foxwell M H, Alphin R S

出版信息

Int Arch Allergy Appl Immunol. 1984;74(4):351-5. doi: 10.1159/000233572.

Abstract

A visual method for measuring increase in tracheal mucus gel layer thickness as an indication of an immediate hypersensitivity response, using a Zeiss slitlamp and pachymeter is described. Mucus gel layer thickening is antigen dose dependent. Antigen challenge of nonsensitized rats does not cause significant increases in gel thickness dispelling the notion that changes in the gel layer result from nonspecific irritation. Cromolyn sodium, cimetidine, and FPL-55712 inhibit increases in gel layer thickness following antigen challenge of actively sensitized rats, while atropine, pyrilamine, and methysergide do not.

摘要

本文描述了一种使用蔡司裂隙灯和测厚仪测量气管黏液凝胶层厚度增加的视觉方法，以此作为速发型超敏反应的指标。黏液凝胶层增厚呈抗原剂量依赖性。对未致敏大鼠进行抗原攻击不会导致凝胶厚度显著增加，这消除了凝胶层变化是由非特异性刺激引起的观念。色甘酸钠、西咪替丁和FPL - 55712可抑制主动致敏大鼠抗原攻击后凝胶层厚度的增加，而阿托品、吡苄明和甲基麦角新碱则无此作用。