Reader M J
J Pharm Sci. 1984 Jun;73(6):840-1. doi: 10.1002/jps.2600730637.
Storage tests on the stability of thimerosal in trimethoprim-polymyxin B eyedrop formulations containing isotonic agents other than sodium chloride have been carried out. The HPLC assay of thimerosal in stored formulations containing boric acid and EDTA decreased with time and temperature, while formulations containing propylene glycol, glycerol, and mannitol showed no significant decrease in thimerosal assay compared with a formulation containing no isotonic agent. The latter group provide suitable alternatives to sodium chloride, which has been shown to have a seriously detrimental effect on thimerosal stability.
已对硫柳汞在含有除氯化钠以外等渗剂的甲氧苄啶-多粘菌素B滴眼液制剂中的稳定性进行了储存试验。储存的含有硼酸和乙二胺四乙酸（EDTA）的制剂中硫柳汞的高效液相色谱（HPLC）测定值随时间和温度降低，而含有丙二醇、甘油和甘露醇的制剂与不含等渗剂的制剂相比，硫柳汞测定值无显著下降。后一组制剂为氯化钠提供了合适的替代物，氯化钠已被证明对硫柳汞稳定性有严重不利影响。
