Sasaki J, Kawano T, Sasaki Y, Ishihara Y, Sata T, Arakawa K
Jpn Circ J. 1984 Jun;48(6):546-51. doi: 10.1253/jcj.48.546.
The concentrations of lipids and apolipoproteins in serum following onset of acute myocardial infarction were measured periodically in eleven patients for 28 days. Significant and sustained decrease in the concentration of HDL-cholesterol was observed by the seventh days post-infarction and remained low throughout the remainder of the study. The concentration of apo A-I and apo A-II assayed by electroimmunoassay was significantly low by 4th and 5th days post-infarction, remained low until day 10 and then began to increase but were not back to the initial values by 28 days post-infarction. Apo B, C-I, C-II, C-III, and E levels remained unchanged throughout the course. The concentrations of total cholesterol, triglycerides tended to fall reaching the lowest levels on day 7 and 10, but were not significant. The concentration of serum phospholipids level tended to decrease and fall significantly by day 7 and 10. The concentration of the free fatty acids in the serum was elevated during the first 2 days post-infarction and was within the normal range throughout the remainder of the study.
对11例急性心肌梗死患者在发病后的28天内定期测定血清脂质和载脂蛋白浓度。在梗死发生后的第7天观察到高密度脂蛋白胆固醇浓度显著且持续下降，并在研究的剩余时间内一直保持在较低水平。通过电免疫测定法检测的载脂蛋白A-I和载脂蛋白A-II浓度在梗死发生后的第4天和第5天显著降低，在第10天之前一直保持较低水平，然后开始升高，但在梗死发生后的第28天仍未恢复到初始值。载脂蛋白B、C-I、C-II、C-III和E水平在整个过程中保持不变。总胆固醇、甘油三酯浓度趋于下降，在第7天和第10天达到最低水平，但差异不显著。血清磷脂水平趋于下降，并在第7天和第10天显著下降。血清游离脂肪酸浓度在梗死发生后的前两天升高，在研究的剩余时间内均在正常范围内。
