[接种物效应对5种β-内酰胺类药物抗铜绿假单胞菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）的影响]
[Influence of the inoculum effect on the MIC and MBC of 5 beta-lactams against Pseudomonas aeruginosa].
作者信息
Croize J, Le Noc P, Robert J
出版信息
Pathol Biol (Paris). 1984 May;32(5):412-4.
PMID:6429613
Abstract
MICs and MBCs of five beta-lactams , i.e. ticarcillin, azlocillin, piperacillin, cefsulodin and ceftazidime for 20 strains of Pseudomonas aeruginosa were studied with inocula ranging from 10(3) to 10(9) CFU/ml. Each antibiotic exhibited an inoculum effect at 10(5)-10(7) CFU/ml. However, ticarcillin had smaller MIC and MBC increments than the four other drugs, making it more suitable in certain cases.
摘要
研究了替卡西林、阿洛西林、哌拉西林、头孢磺啶和头孢他啶这五种β-内酰胺类抗生素对20株铜绿假单胞菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC），接种菌量范围为10³至10⁹CFU/ml。每种抗生素在10⁵ - 10⁷CFU/ml时均表现出接种量效应。然而，替卡西林的MIC和MBC增量比其他四种药物小，在某些情况下更适用。
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