Wigell A H, Overstreet D H
Psychopharmacology (Berl). 1984;83(1):88-92. doi: 10.1007/BF00427429.
Two groups of adult male rats were injected daily with ethanol (1.5 g/kg IP in 15% w/v solution) either before (the behaviourally augmented tolerant group) or after (the physiologically tolerant group) being placed in operant chambers. The control groups received daily isotonic saline injections either before or after the operant task. When challenged with ethanol (2.5 g/kg) on day 30 prior to the operant task, the control group was most impaired, while the behaviourally augmented tolerant group was significantly less impaired than the physiologically tolerant group. The two ethanol-treated groups were impaired to the same extent when challenged on day 60. Partial generalization of this behavioural tolerance to ethanol was observed, as the behaviourally augmented tolerant group was less impaired than the physiologically tolerant group for a tail flick response to painful stimuli after an ethanol challenge on day 30. However, the two ethanol-treated groups exhibited similar impairments of locomotor activity after an ethanol challenge on day 40. No differences in muscarinic receptor binding among the control and two ethanol-treated groups were found. These findings demonstrate that behaviourally augmented tolerance to ethanol may be partially generalizable but is unrelated to changes in muscarinic cholinergic receptors.
将两组成年雄性大鼠每日注射乙醇（以15% w/v溶液腹腔注射1.5 g/kg），一组在放入操作性条件反射箱之前注射（行为增强耐受性组），另一组在放入之后注射（生理耐受性组）。对照组在操作性任务之前或之后每日注射等渗盐水。在操作性任务前第30天用乙醇（2.5 g/kg）进行激发试验时，对照组受损最严重，而行为增强耐受性组的受损程度明显低于生理耐受性组。在第60天进行激发试验时，两个乙醇处理组的受损程度相同。观察到这种对乙醇的行为耐受性有部分泛化现象，因为在第30天乙醇激发试验后，对于疼痛刺激的甩尾反应，行为增强耐受性组的受损程度低于生理耐受性组。然而，在第40天乙醇激发试验后，两个乙醇处理组的运动活动受损情况相似。在对照组和两个乙醇处理组之间未发现毒蕈碱受体结合存在差异。这些发现表明，对乙醇的行为增强耐受性可能有部分可泛化性，但与毒蕈碱胆碱能受体的变化无关。
