Kurunmäki H, Toivonen J, Lähteenmäki P L, Luukkainen T
Contraception. 1984 May;29(5):411-21. doi: 10.1016/0010-7824(84)90015-5.
Seven women used an ST-1435-releasing intracervical contraceptive device (ST-ICD), inserted immediately after the cessation of menstrual bleeding. Patterns of bleeding and clinical performance were evaluated and plasma concentrations of ST-1435, estradiol, progesterone and gonadotropins were measured by radioimmunoassays. The results of ten months of treatment are presented. There were no uniform patterns of bleeding. No hormonal side-effects were registered. The plasma concentration of ST-1435 reached 100 pg/ml within two hours after insertion of an ST-ICD. No ovulations occurred during the initial three months of treatment. A rapid decline in the plasma concentrations of ST-1435 was observed; during the tenth month the concentration of ST-1435 was under the sensitivity of the radioimmunoassay of ST-1435. Hence, the release of ST-1435 from Silastic was too rapid for long-acting contraceptive purposes.
七名女性使用了一种释放ST - 1435的宫颈内避孕装置（ST - ICD），在月经出血停止后立即插入。评估了出血模式和临床表现，并通过放射免疫测定法测量了ST - 1435、雌二醇、孕酮和促性腺激素的血浆浓度。给出了十个月的治疗结果。出血模式不统一。未记录到激素副作用。插入ST - ICD后两小时内，ST - 1435的血浆浓度达到100 pg/ml。治疗的最初三个月内未发生排卵。观察到ST - 1435的血浆浓度迅速下降；在第十个月，ST - 1435的浓度低于ST - 1435放射免疫测定的灵敏度。因此，从硅橡胶中释放的ST - 1435太快，无法达到长效避孕的目的。
