脑膜炎奈瑟菌H血清群荚膜抗原的结构

Structure of the capsular antigen of Neisseria meningitidis serogroup H.

作者信息

van der Kaaden A, van Doorn-van Wakeren J I, Kamerling J P, Vliegenthart J F, Tiesjema R H

出版信息

Eur J Biochem. 1984 Jun 15;141(3):513-9. doi: 10.1111/j.1432-1033.1984.tb08222.x.

DOI:10.1111/j.1432-1033.1984.tb08222.x

Abstract

The capsular polysaccharide of Neisseria meningitidis serogroup H is composed of the following repeating unit, Gro = glycerol; (formula; see text) Partial O-acetylation of the D-Galp moieties is found for C-2 (21%) and C-3 (57%). The structural elucidation of the biopolymer is based on sugar analysis, methylation analysis, partial acid hydrolysis, using gas-liquid chromatography/mass spectrometry studies, and NMR spectroscopy with 1H, 13C and 31P.

摘要

脑膜炎奈瑟菌H群的荚膜多糖由以下重复单元组成，Gro = 甘油；（化学式；见正文）发现D-Galp部分在C-2（21%）和C-3（57%）处存在部分O-乙酰化。该生物聚合物的结构解析基于糖分析、甲基化分析、部分酸水解、气液色谱/质谱研究以及1H、13C和31P的核磁共振光谱。