Szperalski B, König W
Immun Infekt. 1984 Jun;12(3):163-77.
The activation of B-cells can be studied by in vitro experiments. Various stages have been described: activation, proliferation and isotype specific differentiation into plasma cells are regulated by T-cells and macrophages. Their function is in part replaced by soluble factors. The availability of lymphokines derived from cloned T-cells allows a more precise analysis of the various differentiation steps for B-cells. A summary of the various lymphokines obtained from the murine and human system is demonstrated. As has been shown lymphokines reveal immunoregulatory properties which have to be correlated to in vitro results. The various unresolved questions concerning IgE-antibody regulation will be clarified when more defined lymphokines are available.
B细胞的激活可以通过体外实验进行研究。已经描述了各个阶段：激活、增殖以及向浆细胞的同种型特异性分化由T细胞和巨噬细胞调节。它们的功能部分由可溶性因子替代。源自克隆T细胞的淋巴因子的可得性使得对B细胞各种分化步骤的分析更加精确。展示了从鼠类和人类系统中获得的各种淋巴因子的总结。如已表明的，淋巴因子显示出免疫调节特性，这些特性必须与体外实验结果相关联。当有更多明确的淋巴因子时，关于IgE抗体调节的各种未解决问题将得到阐明。
