Antoniades D Z, Schwartz J, Shklar G
J Clin Lab Immunol. 1984 May;14(1):17-22.
Peritoneal macrophages derived from normal and 7,12-dimethylbenz(a) anthracene (DMBA) treated, tumor bearing, Syrian hamsters were isolated and characterized. Peritoneal exudate cells from tumor bearing animals as compared to normal controls, showed that there was an increase in the total number of cells in the exudate. Specifically, there was an increase in macrophages as compared to other cell types. In terms of their cytochemical functions, these macrophages demonstrated a reduction in histochemical activity and functional capacity (Fc and C3 receptors), and cytotoxic specific lysis of DMBA squamous cell carcinoma tumor targets. There was also a significant increase in adherence and the number of resident macrophages as opposed to exudate macrophages of the peritoneal macrophages. These results seem to indicate an alteration in functional and cytochemical activity of macrophages derived from a hamster with a growing cheek pouch tumor induced by DMBA.
从正常叙利亚仓鼠以及经7,12-二甲基苯并(a)蒽（DMBA）处理且患有肿瘤的叙利亚仓鼠中分离并鉴定了腹膜巨噬细胞。与正常对照组相比，来自荷瘤动物的腹膜渗出细胞显示渗出液中细胞总数增加。具体而言，与其他细胞类型相比，巨噬细胞数量增加。就其细胞化学功能而言，这些巨噬细胞的组织化学活性和功能能力（Fc和C3受体）降低，并且对DMBA鳞状细胞癌肿瘤靶标的细胞毒性特异性裂解作用减弱。与腹膜巨噬细胞的渗出性巨噬细胞相比，黏附性和常驻巨噬细胞数量也显著增加。这些结果似乎表明，DMBA诱导的颊囊肿瘤生长的仓鼠来源的巨噬细胞在功能和细胞化学活性方面发生了改变。
