Theodore W H, Newmark M E, Desai B T, Kupferberg H J, Penry J K, Porter R J, Yonekawa W D
Neurology. 1984 Aug;34(8):1100-2. doi: 10.1212/wnl.34.8.1100.
We investigated the conversion of mephenytoin to nirvanol in five patients with uncontrolled complex partial seizures. After a 50-mg single oral dose, mean peak mephenytoin level was 0.48 microgram/ml and nirvanol 0.37 microgram/ml. After 400 mg, peak mephenytoin level was 3.9 micrograms/ml and nirvanol 2.5 micrograms/ml. On 400 mg daily, mephenytoin reached a mean steady-state level of 1.5 micrograms/ml. Nirvanol mean steady-state level was 18 micrograms/ml. Mean plasma half-life was 17 hours for mephenytoin and 114 hours for nirvanol. Two patients had reduced seizures during mephenytoin therapy and one a transient increase during drug withdrawal. No toxicity was seen, but mephenytoin was not more effective than phenytoin.
我们研究了5例复杂部分性癫痫发作未得到控制的患者中，美芬妥因向尼凡诺的转化情况。单次口服50毫克后，美芬妥因的平均峰值水平为0.48微克/毫升，尼凡诺为0.37微克/毫升。服用400毫克后，美芬妥因的峰值水平为3.9微克/毫升，尼凡诺为2.5微克/毫升。每日服用400毫克时，美芬妥因的平均稳态水平为1.5微克/毫升。尼凡诺的平均稳态水平为18微克/毫升。美芬妥因的平均血浆半衰期为17小时，尼凡诺为114小时。两名患者在美芬妥因治疗期间癫痫发作减少，一名患者在停药期间短暂增加。未观察到毒性，但美芬妥因并不比苯妥英更有效。
