Mitomycin C induced chromosome damage in fetal blood cultures and prenatal diagnosis of Fanconi's anaemia.
作者信息
Shipley J, Rodeck C H, Garrett C, Galbraith J, Giannelli F
出版信息
Prenat Diagn. 1984 May-Jun;4(3):217-21. doi: 10.1002/pd.1970040310.
PMID:6431403
Abstract
We report the use of fetal blood for the prenatal diagnosis of Fanconi anaemia (FA). The clastogenic action of Mitomycin C (MMC) is compared in blood cultures from different fetuses, normal controls and FA heterozygotes. The fetus at risk is shown to suffer from FA on the grounds of excessive chromosome breakage, both spontaneous and MMC induced.
摘要
Zotero 插件